The impact of obesity on the development of certain cancers in patients with type 2 diabetes

The aim of the study was to investigate effect obesity on development cancer certain localizations in patients with type 2 diabetes mellitus (T2D) and explain association mechanisms cancer. included retrospective analysis first time diagnosed cases T2D 2012-2016 Ivano-Frankivsk region. Analysis data carried out using Statistica 12.0 (StatSoft Inc., USA) program. are presented tables as M ± SD (M standard deviation). Differences between studied parameters were determined ANOVA- test, taking into account Bonferroni correction. relationship evaluated criterion chi-square Yates correction (?²). odds ratio (OR), 95% confidence interval, positive negative predictive value calculated determine two events. differences considered significant at p < 0.05. According results, 533 detected T2D. It found that is inherent women breast, uterine, ovarian colorectal cancer; for men prostate ?², incidence breast (x2=8.46; p<0.05), (x2=7.02; p<0.05) (x2=7.94; proven. OR revealed an increased risk [OR=2.06; CI (1.28-3.29); p<0.05], [OR=2.94; (1.37-6.32); p<0.05] [OR=2.87; (1.42-5.82); associated obesity. Thus, among T2D, increases women, men. hyperglycemia, hyperinsu­li­nemia, cytokine imbalance, hyperestrogenism (in estrogen-dependent cancer), intestinal dysbiosis cancer).